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Measles

Measles morbillivirus · Paramyxoviridae

Strains

  • Measles morbillivirus — single serotype; 24 recognized genotypes (A, B1–B3, C1–C2, D1–D11, E, F, G1–G3, H1–H2); WHO reference strains used for surveillance: B3, D8, D9, H1

Transmission

  • Airborne — virus suspended in respiratory aerosols lingers in the air and on surfaces for up to 2 hours after an infected person has left the room; this makes indoor spaces highly risky without adequate ventilation
  • Droplet spread — coughing, sneezing, or talking by an infectious person releases virus-laden particles that infect susceptible individuals at close range
  • Highly contagious: basic reproduction number (R₀) 12–18 among the highest of any known pathogen; a single infectious person can transmit measles to 12–18 unvaccinated contacts
  • Infectious window: 4 days before rash appears through 4 days after rash onset (total ~8 days of contagiousness)
  • No animal reservoir — measles is exclusively a human pathogen; global elimination is theoretically achievable with sustained ≥95% two-dose MMR coverage

Symptoms

Prodromal phase — days 1–4 before rash

  • High fever — often ≥40°C (104°F), typically the first symptom
  • Cough — persistent, dry (the first of the '3 Cs')
  • Coryza — runny nose and nasal congestion (the second 'C')
  • Conjunctivitis — red, watery, light-sensitive eyes (the third 'C')
  • Koplik's spots — tiny white or grey-blue dots on bright-red buccal mucosa inside cheeks; pathognomonic for measles, appear 1–2 days before the rash and fade once rash emerges

Exanthematous phase — days 4–7 rash

  • Maculopapular (flat-then-raised blotchy) rash starting at the hairline and face
  • Rash spreads cephalocaudally over 3 days — from face to neck, trunk, arms, legs, and feet
  • Rash blanches on pressure early; later may coalesce and become non-blanching
  • Fever peaks as rash appears, then gradually falls if uncomplicated
  • Rash fades in same order it appeared, leaving a brownish discolouration then fine desquamation

Complications — higher risk in <5 years, adults, immunocompromised, malnourished

  • Otitis media (middle ear infection) — most common complication, ~1 in 10 children with measles
  • Pneumonia — leading cause of measles deaths; viral or secondary bacterial (Streptococcus pneumoniae, Haemophilus influenzae)
  • Croup, bronchitis — additional respiratory complications
  • Diarrhoea — especially in developing world, contributes to dehydration deaths
  • Encephalitis — 1–2 per 1,000 cases; can cause permanent brain damage, deafness, or death
  • Subacute sclerosing panencephalitis (SSPE) — fatal brain disease occurring 7–10 years post-infection; ~1 per 10,000 cases, higher risk if infected before age 2
  • Immune amnesia — measles deletes 11–73% of pre-existing antibody repertoire for 2–3 years post-recovery, greatly increasing susceptibility to other infections
Incubation
7–14 days from exposure to fever onset (range 7–21 days); rash typically appears 2–4 days after fever begins
Mortality rate
0.01–0.1% in high-income settings with good healthcare access; 1–5% in low-resource settings; up to 10–25% in malnourished children or severely immunocompromised individuals
Vaccine
Yes

Treatment

No approved specific antiviral. Management is supportive: fluids and fever control, vitamin A supplementation (WHO-recommended for all children with measles — two doses reduce severity and mortality), treatment of secondary bacterial infections (pneumonia, otitis media) with antibiotics. Severe cases require hospitalization; encephalitis cases require intensive care.

Vaccine status

MMR (measles-mumps-rubella) vaccine and MMRV (adds varicella) are both FDA-approved and WHO-prequalified. Two-dose schedule — first dose at 12–15 months, second at 4–6 years — confers ~97% protection (one dose: ~93%). Recommended in all 194 WHO member states. Vaccine requires cold chain (2–8°C). Vaccine-derived immunity is lifelong in the vast majority of recipients. Lapsed coverage — not viral mutation — drives all recent resurgences including the 2025–2026 USA outbreak.

Endemic regions

  • United States — ongoing 2025–2026 outbreak with over 2,104 confirmed cases reported to the CDC by mid-2026, the highest count since measles was declared eliminated in 2000; concentrated in communities with low two-dose MMR coverage in states including Texas, Montana, and others
  • Europe — Romania, Italy, Kyrgyzstan, Kazakhstan and others reporting active circulation 2025–2026; WHO European Region faces endemic re-establishment in areas with two-dose coverage below 95%
  • Democratic Republic of the Congo — endemic with the world's highest measles burden (>100,000 cases annually in recent years); DRC children under 5 most at risk
  • Sub-Saharan Africa — endemic transmission across multiple countries; WHO African Region accounts for the majority of global measles deaths
  • South and Southeast Asia — large susceptible populations in India, Pakistan, Indonesia; periodic large outbreaks
  • Yemen, Somalia, Ethiopia, Nigeria — ongoing high-burden transmission compounded by conflict and healthcare disruption
  • Western Pacific — resurgent clusters in Philippines, Papua New Guinea, and Pacific island nations with historical vaccination gaps

Frequently asked questions

Sources

Last update Jun 20, 2026 · ⚠ Not medical advice.